This is a weird one.
Mike and Julie dated for 2 years before deciding to get married. Come wedding night she suffered from intense pain like someone was sticking needles inside her. Numerous medical tests later the verdict is out. She has seminal plasma hypersensitivity. In layman's terms she is allergic to her husband's sperms. This is the first time I have heard of such a thing. Well stranger things have happened, I guess. But due to her condition they have no chances of her conceiving a baby of their own. Sad. Of course they have not given up hope, they are now actively participating in adoption procedures.